1. From the Departments of Pharmacology (L.L., K.L.N., Y.C., S.W.L., R.B., P.K.M.) and Chemistry (Y.Y.G., Y.Z., C.T.), National University of Singapore, Singapore; Pharmaceutical Science Division, King’s College, London, UK (L.L., P.K.M.); and Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK (M.W.).