Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation

Author:

Mauler Maximilian123,Herr Nadine23,Schoenichen Claudia23,Witsch Thilo2,Marchini Timoteo23,Härdtner Carmen23,Koentges Christoph23,Kienle Korbinian14,Ollivier Véronique56,Schell Maximilian23,Dorner Ludwig23,Wippel Christopher23,Stallmann Daniela23,Normann Claus27,Bugger Heiko23,Walther Paul8,Wolf Dennis239,Ahrens Ingo3,Lämmermann Tim4,Ho-Tin-Noé Benoît56,Ley Klaus9,Bode Christoph23,Hilgendorf Ingo23,Duerschmied Daniel23

Affiliation:

1. Faculty of Biology (M.M., K.K.), University of Freiburg, Germany.

2. Faculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.

3. Department of Cardiology and Angiology I, Heart Center (M.M., N.H., C.S., T.M., C.H., C.K., M.S., L.D., C.W., D.S., H.B., D.W., I.A., C.B., I.H., D.D.), University of Freiburg, Germany.

4. Max Planck Institute of Immunobiology and Epigenetics, Group Immune Cell Dynamics (K.K., T.L.), Germany.

5. INSERM Unit 1148, University Paris Diderot (V.O., B.H-T-N.), France.

6. Laboratory for Vascular Translational Science, Sorbonne Paris Cité (V.O., B.H-T-N.), France.

7. Department of Psychiatry, University Medical Center Freiburg (C.N.), Germany.

8. Central Facility for Electron Microscopy, Ulm University; Ulm, Germany (P.W.).

9. La Jolla Institute for Allergy and Immunology, La Jolla, CA (D.W., K.L.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference50 articles.

1. Myocardial Reperfusion Injury

2. Myocardial ischemia-reperfusion injury: a neglected therapeutic target

3. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations.;Hausenloy DJ;Eur Heart J,2017

4. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge.;Heusch G;Eur Heart J,2017

5. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury

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