A Critical Need for Clinical Context in the Genomic Era

Author:

MacRae Calum A.1

Affiliation:

1. From Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; and the Broad Institute of Harvard and MIT, Cambridge, MA.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference12 articles.

1. Positional cloning: Let's not call it reverse anymore

2. Actionable exomic incidental findings in 6503 participants: challenges of variant classification

3. Revisiting risk stratification in hypertrophic cardiomyopathy: Do we need to start from scratch?

4. Aronson SJ Clark EH Varugheese M Baxter S Babb LJ Rehm HL. Communicating new knowledge on previously reported genetic variants [published online ahead of print April 5 2012]. Genet Med . doi: 10.1038/gim.2012.19. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841913/. Accessed August 18 2015.

5. High prevalence of genetic variants previously associated with Brugada syndrome in new exome data

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