1. From the Departments of Pharmacology and Cell Biophysics (X.W., X.Z., X.-P.R., G.-C.F.), Environmental Health (J.C., M.M.), and Cancer and Cell Biology (H.L., J.Y.), University of Cincinnati College of Medicine, Cincinnati, Ohio, and Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China (Z.H.).