1. From the Institute for Translational Medicine and Therapeutics (L.C., G.Y., G.G., J.A.L., G.A.F.), Department of Pharmacology (L.C., G.Y., G.G., J.A.L., G.A.F.), University of Pennsylvania, Philadelphia, PA; and RAD-Transgenics, Discovery Sciences, Astra Zeneca R&D, Mölndal, Sweden (X.X., M.B.-Y.).