1. From the Department of Genetics and Penn Center for Bioinformatics (S.H., J.W.), Department of Biostatistics, Center for Clinical Epidemiology and Biostatistics (M.E.P.), and Penn Cardiovascular Institute (J.M.G., M.S.P., J.A.E., E.E.M., K.B.M., T.P.C.), University of Pennsylvania School of Medicine, Philadelphia.