1. From Brigham & Women’s Hospital, Harvard Medical School, Boston, MA (A.P.C.); Institute of Cardiology and Center of Excellence on Aging, G. d’Annunzio University, Chieti, Italy (R.D.C., G.R.); Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York (J.L.H.); TIMI Study Group (Thrombolysis in Myocardial Infarction), Boston, MA (C.T.R., M.T., F.N., E.A., R.P.G.); and Daiichi Sankyo Pharma Development, Edison, NJ (M.P.M.).