1. From Birmingham University (A.R.M., P.G., K.A., I.A., R.A.W., P.T., M.P.F.), Birmingham, United Kingdom; School of Medicine, Cardiff University (A.B.M., P.E.J.), Cardiff, United Kingdom; Department of Cardiovascular Medicine (H.A.), University of Oxford, Oxford, United Kingdom; and William Harvey Research Institute (G.V.R.B.), London, United Kingdom.