1. From Divisions of Cardiology (D.H.F.) and Cardiac Surgery (S.V.), Li Ka Shing Knowledge Institute (D.H.F., S.V.) and Keenan Research Centre for Biomedical Science (S.V.), St. Michael’s Hospital, Toronto, ON, Canada; Departments of Medicine (D.H.F.) and Surgery (S.V.), University of Toronto, ON, Canada; and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (R.A.H.).