1. From the Institute for Translational Medicine and Therapeutics (M.W., D.K., Z.Y., L.C., Y.C., J.A.L., R.K.A., G.A.G., K.I.-S., G.G., P.L.J.), Department of Pharmacology (M.W., D.K., Z.Y., L.C., Y.C., J.A.L., R.K.A., G.A.G.), and Institute for Medicine and Engineering (K.I.-S., M.C.T., P.L.J), Department of Pathology and Laboratory Medicine (K.I.-S., G.G., P.L.J.), University of Pennsylvania, Philadelphia.