Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension

Author:

Yuan Ke123,Shamskhou Elya A.123,Orcholski Mark E.123,Nathan Abinaya123,Reddy Sushma24,Honda Hiroaki5,Mani Vigneshwaran6,Zeng Yitian7,Ozen Mehmet O.26,Wang Lingli238,Demirci Utkan6,Tian Wen239,Nicolls Mark R.239,de Jesus Perez Vinicio A.123

Affiliation:

1. Division of Pulmonary and Critical Care Medicine (K.Y., E.A.S., M.E.O., A.N., V.A.d.J.P.), Stanford University, Palo Alto, CA.

2. Stanford Cardiovascular Institute (K.Y., E.A.S., M.E.O., A.N., S.R., M.O.O, L.W., W.T., M.R.N., V.A.d.J.P.), Stanford University, Palo Alto, CA.

3. Wall Center for Pulmonary Vascular Research (K.Y., E.A.S., M.E.O., A.N., L.W., W.T., M.R.N., V.A.d.J.P.), Stanford University, Palo Alto, CA.

4. Division of Pediatric Cardiology (S.R.), Stanford University, Palo Alto, CA.

5. Field of Human Disease Models, Major in Advanced Life Sciences and Medicine, Institute of Laboratory Animals, Tokyo Women’s Medical University, Japan (H.H.).

6. Department of Radiology, Canary Center for Early Cancer Detection (V.M., M.O.O., U.D.), Stanford University, Palo Alto, CA.

7. Department of Materials Science and Engineering (Y.Z.), Stanford University, Palo Alto, CA.

8. Department of Pediatrics (L.W.), Stanford University, Palo Alto, CA.

9. Department of Medicine, VA Palo Alto Health Care System/Stanford University, CA (W.T., M.R.N.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference47 articles.

1. The role of pericytes in angiogenesis

2. Pericyte biology and diseases.;Yamagishi S;Int J Tissue React,2005

3. Pericytes: morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche.;Díaz-Flores L;Histol Histopathol,2009

4. Cytoskeletal features of alveolar myofibroblasts and pericytes in normal human and rat lung.

5. Bone Morphogenetic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival

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