1. From the Department of Bio-Informational Pharmacology, Medical Research Institute (H.N., J.K., C.-X.B., K.A., T.F.) and Department of Cardiovascular Medicine, Graduate School of Medicine (H.N., M.I.), Tokyo Medical Research Institute, Tokyo, Japan, and Department of Physiology and Biophysics (J.X., R.V.O., Z.I.Z., C.E.C.), Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY.