1. From the Laboratory of Experimental Cardiology, University Medical Center Utrecht (F.A., M.B.S., L.T., C.T., I.E.H., P.A.D., G.P., D.P.V.d.K.), and Interuniversity Cardiology Institute of the Netherlands (F.A., P.A.D., G.P., D.P.V.d.K.), Utrecht, the Netherlands; School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland (L.A.J.O.); and Opsona Therapeutics Ltd, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland (B.K., P.M.).