1. From the Departments of Pathology and Preclinical Biology, Genzyme Corporation, Cambridge, Mass (B.L.T., M.W.O.); Department of Pathology, Mount Sinai School of Medicine, New York, NY (J.T.F., R.E.G.); Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass (R.M.); and Department of Pathology, Massachusetts General Hospital, Boston, Mass (T.A.).