1. Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences (L.N.H.), and Toshiba Stroke and Vascular Research Center (L.N.H.), University at Buffalo, State University of New York (L.N.H.); Gates Vascular Institute at Kaleida Health, Buffalo, NY (L.N.H.); Jacobs Institute, Buffalo, NY (L.N.H.); and Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (D.R.H.).