1. From the BHF Centre of Research Excellence, Division of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK (L.M.F., G.D., J.K.B., E.M., M.J.C., A.B.H., M.A.M., J.E.S., R.P.L., K.M.C.); and Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK (A.M., J.-M.L.).