1. From the Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital (K.M.M.-P., M.E., J.C., I.B.W.); Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital (M.E., F.R.J., J.H.F.R.); and Department of Rheumatology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (A.J.K.Ö., F.C.H.).