1. From the Department of Biochemistry, Research Institute (T.T., I.K., T.S., K.M., K.K.) and Department of Medicine (T.H., Y.K.), National Cardiovascular Center, Suita, Osaka, Japan; the Second Department of Internal Medicine (M.K.), Kagawa University Faculty of Medicine, Kagawa, Japan; the Howard Hughes Medical Institute and Department of Pharmacology (D.L.G), University of Texas Southwestern Medical Center at Dallas; and the Department of Medicine and Clinical Science (K.N), Kyoto University...