1. From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (S.M., T.M., A.M., R.N., T. Kita); the Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan (T. Kawamura, K.O., H.W., K.H.); and the Chugai Research Institute for Medical Science, Inc, Pharmacology & Pathology Research Center, Shizuoka, Japan (Y.K.).