1. From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY (C.L.W., Y.S., V.L., N.S., M.I., S.S., R.L., A.G., N.P., K.C.-F., J.M.D., A.R.T.); Bristol-Myers Squibb, Pennington, NJ (B.J.A., M.L.O.); and University of British Columbia, Vancouver, BC (Y.Y., D.B.).