1. From Department of Physiology, Ted Rogers Centre for Heart Research, University of Toronto, Canada (A.G., P.P.L.); NIH BD2K Center of Excellence in Biomedical Computing, Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA (E.L.); and University of Ottawa Heart Institute, Departments of Medicine & Cellular Molecular Medicine, University of Ottawa, Canada (P.P.L.).