1. From Department of Pharmacology (Z.D., M.L., M.M.Z., Y.-Y.Z.) and Center for Lung and Vascular Biology (Z.D., M.L., M.M.Z., Y.-Y.Z.), University of Illinois College of Medicine, Chicago; and Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College of London, Hammersmith Hospital, UK (J.W.).