Studies of the Effect of Antiarrhythmic Drugs on Carbohydrate Metabolism of Rat Heart Muscle in Vitro

Author:

HESS MARILYN E.1,HAUGAARD NIELS1

Affiliation:

1. Laboratory of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pa.

Abstract

The effect of antiarrhythmic drugs on the oxidation of glucose by heart tissue was studied. Quinine and quinidine inhibited oxygen consumption and glucose utilization by rat heart slices and homogenates, while chloroquine and procaine amide had little effect.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference11 articles.

1. The metabolism of the heart in relation to drug actions;WEBB J. L.;J. Pharmacol. & Exper. Therap.,1951

2. The biochemistry of the malaria parasite: III. The effects of quinine and atabrine on glycolysis;SPECK J. F.;J. Biol. Chem.,1945

3. UYEKI M. GEILJNG E. M. K. AND DUBOIS K. P.: Studies of the effects of quinidine on intermediary carbohydrate metabolism. Arch internet pharmacodyn. 97: 191 1954.

4. AND VAN SLYKE, D. D.: A direct mierotitration method for blood sugar;MILLER B. F;J. Biol. Chem.,1936

5. A study of glucose oxidation in whole tissue homogenates;WENNER C. E.;J. Biol. Chem.,1953

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