Polarographic Oxygen, the Epicardial Electrocardiogram and Muscle Contraction in Experimental Acute Regional Ischemia of the Left Ventricle

Author:

SAYEN JOHN J.1,SHELDON WARNER F.1,PEIRCE GEORGE1,KUO PETER T.1

Affiliation:

1. Edward B. Kobinette Foundation, Department of Medicine, the Department of Pathology and the Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia, Pa.

Abstract

This study is the first attempt to correlate myocardial oxygen availability by the polaro-graphic method with direct electrocardiographic leads and cinematographic records of muscle contraction during experimental acute coronary branch occlusion and narrowing. The comparative insensitivity and slowness of the epicardial electrocardiogram as an index of acute regional ischemia is demonstrated. Special attention is given to the rates of myocardial oxygen change immediately following attainment of a significant degree of coronary obstruction, the effects of pure oxygen inhalation on the experimental situations, and alterations in coronary vein color following release of arterial occlusion.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference11 articles.

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2. SAYEN J. J. SHELDON AV. F. HORWITZ O. Kuo P. T. PEIRCE G. ZI.VSSER . H. F. AND MEAD J. HORWITZ 0. AND MCCALLIE D. F.: Studies of coronary disease in the experimental animal. III. Polarographic studies of intramyocardial oxygen availability in dogs with acute coronary occlusion and narrowing correlated with epicardial electrocardiograms. Proc. Am. Soc. Clin. Invest. J. Clin. Invest. 30: 670 1951.

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