Stretch-dependent calcium uptake associated with myogenic tone in rabbit facial vein.

Author:

Laher I1,van Breemen C1,Bevan J A1

Affiliation:

1. University of Vermont, Department of Pharmacology, Burlington 05405.

Abstract

Many blood vessels possess stretch-dependent myogenic tone. This tone contributes to the active resistance in small arteries, which regulates blood flow in the body. In this report we describe results indicating that stretch-dependent myogenic tone in the rabbit facial vein, a vascular preparation with useful experimental properties, is accompanied by an increased uptake of 45Ca2+. This influx may not occur through voltage-gated Ca2+ channels, since neither the extent of myogenic tone nor 45Ca2+ influx is affected by a concentration of 1,4-dihydropyridine (PN 200-110, 10 nM) that reduces tone and 45Ca2+ influx due to the depolarization by K+. These results indicate that in myogenically active vessels a stretch-activated influx of Ca2+ may occur through distinct Ca2+-entry pathways.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference5 articles.

1. Johnson PC: The myogenic response in Bohr DF Somlyo AP Sparks HV (eds): The Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle sec 2 vol II. Baltimore Md Waverly Press 1980 pp 409-442

2. Autoregulation of blood flow;Johnson PC;Ore Res,1986

3. myogenic vascular tone;Blood Vessels,1981

4. . thermoregulation? Science 1980207:1001-1002 Winquist RJ Baskin EP: Calcium channels resistant to organic calcium entry blockers in a rabbit vein. Am J Physiol

5. Pegram BL Bevan RD Bevan JA: Facial vein of the rabbit. 1983;245:H1024-H1030

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