Affiliation:
1. Department of Internal Medicine, University of Minnesota Hospitals, Minneapolis, Minn.
Abstract
After inhibition of spontaneous tone, the contraction of spirally cut strips of aorta in response to norepinephrine was studied quantitatively in normotensive rats and in 4 different types of hypertensive rats. In no instance did the aortas of hypertensive rats show hyper-responsiveness to norepinephrine. The majority of responses were entirely normal; in a few instances there was decreased responsiveness. In vivo studies which fail to consider the critical effect of an altered "base-line" state in hypertension may demonstrate "hyper-responsiveness" which is more apparent than real.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
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