Effects of Ouabain on Force of Contraction, Oxygen Consumption, and Metabolism of Free Fatty Acids in the Perfused Rabbit Heart-Reference-Cited by-同舟云学术

Effects of Ouabain on Force of Contraction, Oxygen Consumption, and Metabolism of Free Fatty Acids in the Perfused Rabbit Heart

Published:1967-10 Issue:4 Volume:21 Page:445-448
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

GOUSIOS ARISTIDES G.¹,FELTS JAMES M.¹²,HAVEL RICHARD J.¹

Affiliation:

1. Cardiovascular Research Institute, Department of Medicine, and Department of Physiology, University of California San Francisco Medical Center, San Francisco, California 94122; and the Permanente Medical Group, Kaiser Foundation Hospital, Richmond, California

2. the National Heart Institute, National Institutes of Health, Bethesda, Maryland.

Abstract

Isolated rabbit hearts were perfused with a suspension of red cells which assured adequate oxygenation. Ouabain added to the perfusate (2.8 x 10 -7 M final concentration) promptly increased the force of contraction and oxygen consumption of the hearts. These events appeared to occur simultaneously. The extraction ratio of palmitate-1- 14 C added to the perfusate (0.31) was not altered by ouabain. However, ouabain increased the oxidation of the extracted palmitate from an average of 34% to an average of 71% at the time intervals studied.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.21.4.445

Reference14 articles.

1. Metabolic effects of ouabain in the perfused rat heart;KHEISBERC R. A.;Am. J. Physiol.,1984

2. Effect of catecholamines, glucose, insulin, and changes of flow on the metabolism of free fatty acids by the myocardium

3. Metabolism of serum triglycerides and free fatty acids by the myocardium;FELTS J. M.;Metabolism,1963

4. A pyrex apparatus for the perfusion of the coronary circulation of mammalian hearts;ANDERSON F.;J. Pharmacol. Exptl. Therap.,1948

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