Role of Acetylstrophanthidin in Augmenting Myocardial Oxygen Consumption

Author:

COLEMAN HENRY NEAL1

Affiliation:

1. Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014

Abstract

A polarographic method was used to determine the effects of acetylstrophanthidin on myocardial oxygen consumption (MV · O 2 ) of 19 cat papillary muscles contracting under both afterloaded and isometric conditions. Under afterloaded conditions, acetylstrophanthidin shifted the force-velocity relation to the right and produced increments in both the extent and velocity of shortening at constant levels of developed force. These changes in myocardial mechanical behavior after strophanthidin were always associated with an increased MV · O 2 . Since both the extent and velocity of shortening increased following augmentation of the contractile state with glycoside, consideration of the individual effect of these variables in myocardial mechanical behavior on MV · O 2 was precluded. Therefore, experiments were performed on isometrically contracting muscle to evaluate the effect of changes in the velocity of contraction on MV · O 2 independent of changes in contractile element shortening. Comparison of the MV · O 2 of isometric contractions at equal levels of developed tension (and thus equivalent amounts of internal contractile element shortening) was accomplished by decreasing initial muscle length after augmentation of the contractile state by acetylstrophanthidin. Under these conditions, augmentation of the contractile state, characterized by an increase in the velocity of contraction, was associated with an increased MV · O 2 . Thus it is concluded that the effect of acetylstrophanthidin is to increase MV · O 2 at a constant load and that this augmentation of MV · O 2 can be related to the change in contractile state of the muscle.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Cited by 89 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Surrogates for myocardial power and power efficiency in patients with aortic valve disease;Scientific Reports;2019-11-11

2. Cardiac Energetics;Muscle and Exercise Physiology;2019

3. Myocardial Oxygen Consumption;Coronary Artery Disease;2018

4. Energetics of the Frank-Starling effect in rabbit myocardium: economy and efficiency depend on muscle length;American Journal of Physiology-Heart and Circulatory Physiology;2002-07-01

5. Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffness;American Journal of Physiology-Heart and Circulatory Physiology;2002-06-01

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3