Inhibition of Incorporation of Leucine into Myocardial Proteins of the Rat by Antiarrhythmic Agents-Reference-Cited by-同舟云学术

Inhibition of Incorporation of Leucine into Myocardial Proteins of the Rat by Antiarrhythmic Agents

Published:1969-10 Issue:4 Volume:25 Page:401-406
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

Beller Barry M.¹,Mongillo Stephen¹

Affiliation:

1. Department of Physiology and Internal Medicine, The University of Texas Medical School at San Antonio San Antonio, Texas 78229 and the Department of Medicine, Albert Einstein College of Medicine Bronx, New York

Abstract

Incorporation of tritiated leucine into myocardial proteins was inhibited at low concentration by quinidine, procaine amide, and diphenylhydantoin, but not by lidocaine or propranolol. This inhibition could be demonstrated in vitro and when the animals were treated with these agents. The relationship between this finding and myocardial depression produced by these antiarrhythmic agents is not known but may reside in general depression of cellular metabolism and protein synthesis or in inhibition of synthesis of a specific membrane carrier protein.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.25.4.401

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