Affiliation:
1. Department of Physiology, University of Ottawa, Ottawa, Canada
Abstract
Cardiac enlargement was produced in three groups of male rats by maintaining them on a diet low in iron. Hearts from anemic rats increased approximately 100% in weight compared to hearts from normal rats. When compared to control cardiac tissue, no consistent significant changes in the
concentration
of DNA, RNA, or protein occurred in any of the groups. The
total
amount of all three constituents increased significantly in the enlarged hearts; this increase was proportional to the degree of cardiac enlargement. The data indicate that nuclear and cytoplasmic material increased equally in cardiac enlargement due to nutritional anemia. This and other observations in the literature suggest hyperplasia as the most likely explanation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
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