Affiliation:
1. Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California 90029, and the Department of Medicine, University of California at Los Angeles, California
Abstract
Analysis of the passive pressure-volume filling curve of the left ventricle demonstrates that heart size and ventricular geometry exert major effects on the pressure-volume curve in the absence of changes in intrinsic muscle stiffness. Because the pressure-volume relationship is curvilinear, both quantitative and qualitative comparison of pressure-volume curves from different hearts is difficult. In the fresh isolated canine left ventricle, the pressure-volume relation was found to be almost perfectly exponential throughout a range of filling pressures from 5 to 30 mm Hg. Therefore, a precise linear and quantitative expression of the pressure-volume relation (dP/dV=aP+b) was developed (r=0.995). The effect of isolated changes in either initial ventricular volume (mean δa=3.1%) or ventricular geometry (mean δa=27.1%) upon the slope, or
a
constant of this function was small in comparison to changes induced by rigor mortis (mean δa =45%). It was concluded that the
a
constant was primarily affected by changes in left ventricular wall stiffness. In this manner, comparison of the pressure-volume relationship from different hearts is possible, and the contribution of changes in wall stiffness may be quantified.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
204 articles.
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