Affiliation:
1. Heart Research Laboratory, Department of Medicine, University of Oregon Medical School Portland, Oregon 97201
Abstract
Oxygen affinity of blood was measured in 16 patients (nonsmokers) without anemia and with clinical evidence of low cardiac output. Of these patients, 12 were catheterized and showed an arteriovenous oxygen concentration difference across the lungs greater than 5 ml/100 ml. The partial pressure of oxygen required to half-saturate their blood with oxygen (P
50
) averaged 29.4 mm Hg (SD ± 1.9). Blood from normal subjects (nonsmokers) had an average P
50
of 27.3 mm Hg (SD ± 0.9). The decreased oxygen affinity found in blood of patients with low levels of cardiac output is considered as a compensatory adjustment to poor tissue blood flow, promoting the diffusion of oxygen from blood in tissue capillaries to intracellular sites of utilizaton.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
77 articles.
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