Affiliation:
1. From the Department of Medicine, Georgetown University Hospital and Georgetown University School of Medicine, and the Veterans Administration Hospital, Washington, D. C.
Abstract
In man, C6, a new ganglionic blocking agent (50 mg. intravenously) produced inhibition of the Valsalva, tiltback and cold pressor vasopressor responses. Marked increases in digital blood flow and skin temperature with inhibition of digital reflexes to "noxious" stimuli were consistently observed (room temperature 70 F.). The increase in skin temperature was greater and more lasting than following Priscoline or tetraethylammonium chloride. Except for severe postural hypotension, side effects were minimal. Clinically the drug may be useful in the evaluation of sympathetic vasoconstriction in peripheral vascular disease as well as in the treatment of acute neurogenic vasospasm.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference21 articles.
1. Central impairment of sympathetic reflexes by plasmochin;MOE G. K.;Federation Proc.,1946
2. Effect of Pentaquine on Cardiovascular System of Unanesthetized Dogs
3. The pharmacology of the natural and dihydrogenated alkaloids of ergot. Bull. schweiz. Akad d. med;ROTHLIN E.;Wissensch.,1947
4. Locus of the adrenergic blocking action of Dibenamine;NICKER ON, M;J. Pharmacol. & Exper. Therap,1948
5. Adrenolytic and Sympatholytic Actions of Priscol (benzyl-imidazoline)
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