1. From the Department of Pharmacology and Toxicology (M.X.v.B., J.-S.R., B.G., F.A., D.D., M.A.T., O.S., H.A.) and Service of Cardiology (H.A.), University of Lausanne, Switzerland; and Department of Pharmacology (M.T., I.R., R.S.K.), Columbia University, New York.