1. From the Department of Medicine (X.Y., L.L., N.R., P.U., T.K.J., H.C., N.W.M.), University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge; the Department of Pathology (M.S., C.A.), Papworth Hospital, Cambridge; and the Division of Clinical Genetics (R.T.), University of Leicester, United Kingdom.