1. From the Departments of Vascular Medicine (R.J.B., J.J.P.K., J.H.M.L., B.v.d.B., J.C.M.M., M.L., E.S.G.S.), Hematology (J.J.Z.), and Experimental Medicine (P.H.R.), Academic Medical Center, Amsterdam, the Netherlands; and Pfizer Global Research and Development (D.H.), Ann Arbor, Mich.