Affiliation:
1. From The Whitaker Biomedical Engineering Institute and Center for Cardiovascular Bioinformatics and Modeling (R.L.W.), The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Md; and the Human Biology Division (M.S.B.), Fred Hutchinson Cancer Research Center, Seattle, Wash.
Abstract
This article reviews recent advances in genomics and informatics relevant to cardiovascular research. In particular, we review the status of (1) whole genome sequencing efforts in human, mouse, rat, zebrafish, and dog; (2) the development of data mining and analysis tools; (3) the launching of the National Heart, Lung, and Blood Institute Programs for Genomics Applications and Proteomics Initiative; (4) efforts to characterize the cardiac transcriptome and proteome; and (5) the current status of computational modeling of the cardiac myocyte. In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference119 articles.
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