1. From the Departments of Geriatric Medicine (B.-K.S., K.K., K.I., M.E., T.K., H.O., Y.S., M.A., Y.O.) and Cardiovascular Medicine (K.M.), Graduate School of Medicine, The University of Tokyo; and Discovery Research Laboratory (T.N.), Shionogi & Co Ltd, Osaka, Japan. Current address for K.K.: Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo, Japan.