1. From the Donald W. Reynolds Cardiovascular Clinical Research Center (K.I., R.K.K., T.Q.), Division of Cardiovascular Medicine, Stanford University School of Medicine, Calif; Department of Clinical Pharmacology (M.K.), Kyoto Pharmaceutical University, Japan; and Department of Cardiology and Vascular Regenerative Medicine (K.I., S.I., H.M.), Kyoto Prefectural University of Medicine, Japan.