1. From the Department of Metabolic Medicine (M.I., H.M., K.T., K.K., T.M., T.K., T. Taguchi, K.N., M.Y., D.K., K.M., T. Toyonaga, T.N., E.A.), Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, and the Department of Physiological Chemistry and Metabolism (T.A.), Graduate School of Medicine, University of Tokyo, Japan.