1. From the Terrence Donnelly Heart Center and Division of Cardiology (K.T.-K., M.J.B.K., M.A.K., G.K., D.W.C., L.Z., D.J.S.), St. Michael’s Hospital, Toronto; University Health Network (J.G.), Toronto; and the Departments of Medicine (M.J.B.K., J.G., D.J.S.) and Laboratory Medicine and Pathobiology (G.K., D.W.C., D.J.S.) and The McLaughlin Center for Molecular Medicine (M.J.B.K., D.J.S.), University of Toronto, Ontario, Canada.