1. From the First Department of Internal Medicine (Y.W., M.M.), Tohoku University School of Medicine, Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; the Departments of Medicine, Physiology, and Biophysics (B.D.S., H.E.D.J.t.K.), Health Sciences Centre, University of Calgary, Canada; and the Department of Pharmacology (P.A.B.), Columbia University, New York.