1. From the Carolina Cardiovascular Biology Center (W.X., T.-C.Z., D.C., D.-Z.W.), Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill; the Department of Molecular Biology (Z.W., C.L.A., S.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas; and the Division of Molecular Medicine (Y.W.), David Geffen School of Medicine, UCLA, Los Angeles, California.