1. From the Department of Medicine III (W.R., G.W., T.D., S.J., N.T., D.H., H.A.K.), University of Heidelberg, Germany; Cardiovascular Research Center (W.R., C.G.B., M.C.F.), Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Mass; and Novartis Institutes for BioMedical Research (M.C.F.), Cambridge, Mass.