1. From the Departments of Cardiovascular Medicine (N.U., M.O., H.Y., A.M., S.M., K.T., T.N., T. Takahashi, T. Tatsumi, H.M.) and Pharmacology (K.M.), Kyoto Prefectural University of Medicine; and Department of Pathology (Y.A.), Kansai Medical University, Osaka, Japan.