1. From the Departments of Neuroscience Therapeutics (G.P.S., N.C.K., P.A.B.), Chemistry (C.F.B.), and Pharmacokinetics, Dynamics Metabolism (D.F.W.), Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, and Department of Surgery (Neurosurgery), University of Michigan (G.P.S.), Ann Arbor, Mich.