1. From the Department of Pharmacology (D.-J.L., Z.-W.Y., S.-W.S., P.W., X.-J.M., C.L., D.-F.S., F.-M.S.), College of Pharmacy, Second Military Medical University, Shanghai, China; School of Life Science and Technology (D.-J.L., T.X.), China Pharmaceutical University, Nanjing, China; and Department of Physiology (R.G.E.), Monash University, Melbourne, Australia.