1. From the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN (N.S.K., C.Y.S., B.L.J., A.M.E., X.R.F., K.U.M.); and Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard Institute of Medicine, Boston, MA (J.V.B.).