1. From the Department of Physiology and Functional Genomics (Z.S., J.Z., P.S., J.Y.J., Y.D., T.M.M., G.J.L., A.C., W.Y., Y.Q., C.S., M.K.R.), Department of Ophthalmology (Q.L.), and Department of Pharmacodynamics (M.J.K.), University of Florida, Gainesville, FL; and School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom (J.F.R.P.).