1. From the Framingham Heart Study, Framingham, MA (S.C., V.X., R.S.V.); Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (S.C.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (V.X., L.M.S.); Preventive Medicine (V.X., R.S.V.) and Cardiology (R.S.V.) Sections, Boston University School of Medicine, Boston, MA.